benefits of hypoxia exposure to the elderly, and potential therapeutic applications of hypoxia for neurodegenerative diseases. Special attention is directed toward the risks vs. It draws upon an extensive literature search on the effects of hypoxia/altitude on brain aging, and detailed analysis of all identified studies directly comparing brain responses to hypoxia in young vs. detrimental impacts on the aging brain and the molecular mechanisms that mediate these divergent effects. This review discusses evidence of hypoxia's beneficial vs. Moreover, controlled hypoxia exposure may represent a treatment strategy for age-related neurological disorders. sojourns or residing at high altitudes, may impart favorable effects on aging and mortality. Conversely, reduced environmental oxygen, e.g. Hypoxia is pivotal to the pathogeneses of myriad neurological disorders, including Alzheimer's, Parkinson's and other age-related neurodegenerative diseases. The journal should have a separate file type for the tracked changes version.The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary disease.The 'clean' version should be uploaded as the primary 'manuscript' file type of the journal,.When uploading your revision, choose the correct item Type for each of the two files.Remove any comments from the 'clean' copy.Then select ' Accept All Changes' and ' Stop Tracking'. In the second 'clean' copy of the file, go to the 'Review' tab and click the arrow next to 'Accept'.After saving, select 'Save As' and change the file name to remove the 'tracked changes' label, for example just 'revision 2.docx' or 'revision 2 clean.docx'.To save a second version without tracked changes: Many journals request two copies of the revision, one with tracked changes, and one without, sometime referred to as the 'clean' version. Once you are finished revising the paper, save the file with a name that clearly shows it has tracked changes enabled, for example 'revision 2 tracked changes.docx'. html), tracked changes will appear on your Web page. If you use change tracking and then save your document as a Web page (.htm or. When submitting the revision, be careful to apply the correct "Item Type" to each file.Save again with a different filename for the clean copy.In your application, find the option to approve all changes, and remove any comments.
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